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Unfortuitously, targeted therapies during the clinical products have had restricted triumph to date, partially as a result of the heterogeneity and you may plasticity regarding GBM and also due to practical limitations(193)
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Considering the genomic difficulty and you will several signaling pathways off GBM, an effective monotherapy wont working. Therefore, to be a success, novel GBM therapies address type of biological pathways and can include novel methodologies such electric field, viral, or cell-centered therapeutic strategies.